stockpikker schreef:
Dit is een MUST read! Echt even lezen!
Another good post...Iplex Vs Increlex
by: zip512003
Long-Term Sentiment: Strong Buy 02/10/06 09:20 am
Msg: 65792 of 65810
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Re: Please give me a rationale argument
by: rfoable1 12/27/05 11:20 pm
Msg: 1478 of 1546
rondon,
iPlex: 31% mild hypoglycemic episodes, 2 of which were "symptomatic" (but not severe) requiring intervention VS
Increlex: 42% mild to moderate hypo episodes, 5 of which were "severe (requiring assistance and treatment)" and 4 involving "seizures and loss of consciousness"
Mild vs moderate are medically very significant differences. It's the compound effect of frequency x severity that physicians pay attention to. "Seizures/loss of consciousness" is a big time red flag. Pediatric endocrinologists will not read those 2 product profiles as "comparable".
1x injection per day vs 2x injection per day is also a huge issue, especially for a home administration drug.
Ask any pharmaceutical marketing or sales professional whether if they would like to sell a 2x per day drug with even a small probability of seizures/loss of consciousness against a 1x per day drug with zero reports of same.
As to diet, Increlex administration is required by the pkg insert to be injected in association within 20 minutes of a meal to avoid hypo episodes. If each of the 2 injections cannot be made within 20 minutes of a snack or meal, the pkg insert says the drug should be "withheld".
iPlex pkg insert simply states that "regular, balanced diet" should be maintained during treatment, and the single daily injection should be withheld if the patient cannot/will not eat or if they completely skip a meal. In other words, as long as they are eating reasonably normally, they can receive the drug anytime in the day - although it should be around the same time each day.
I would not want to be a parent trying to carefully time the eating of my 10 year old kid at two different times per day!
The only disadvantage for iPlex is they have to keep the drug in their freezer until 45 minutes before the single injection. Quite manageable issue since you can easily figure out 1 time per day to take the vial out of the freezer.
Pediatric endocrinologists are not going to want to work through the phone calls of pharmacists and Increlex patients' parents who are going nuts trying to keep the kids on a tight 2x daily meal + injection schedule or, god forbid, deal with one single panic call from an emergency room or kid's parents that are facing a seizure or loss of consciousness.
Really, to be objective, these are not very comparable drugs. I'm not saying Increlex will not have some market share and help kids. But Insmed sales reps will have a dream job. Even if it takes a year or two of competition, over time iPlex is going to look like a superior medication.
imho